EGID Express GWAS

GWAS Viewer

Enter SNP of interest below. This tab contains 8,043,514 SNPs in EoE-1 and EoE-2 regardless of significance.
Auto-fill is not available for this field.

SNP:

EoE-1:
Omni2.5/Omni5
1033 EoE 11354 Control

EoE-2:
GSA/Omni2.5/Omni5
724 EoE 3113 Control

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Table

EoE atopic MTAG

Please select options from top to bottom. Any selection will refresh list of available options below

SNP filter method:

None

Band

Nearest Gene

Manual P-value Threshold

Manual P-value Threshold and Band

Manual P-value Threshold and Nearest Gene

Select band:

Select nearest protein coding gene:

Enter maximum EoE-1 P-value:
Range = 1 to 5e-10
Format as decimals or scientific notation (i.e. 0.00005 or 5e-5)

Select band:

Enter maximum EoE-1 P-value:
Range = 1 to 5e-10
Format as decimals or scientific notation (i.e. 0.00005 or 5e-5)

Select nearest protein coding gene:

SNPs (Ascending EoE atopic MTAG p-value order):

Dataset Information:

Dataset	Platform	Cases	Controls	Neff	Cn/Cs Ratio
Asthma	UKB Axiom/BiLEVE	39409	362366	142174	9.2
Allergic rhinitis	UKB Axiom/BiLEVE	30197	330089	110664	10.9
Atopic dermatitis	UKB Axiom/BiLEVE	13090	330089	50363	25.2
Allergy not specified 1	UKB Axiom/BiLEVE	9345	362366	36440	38.8
Allergy not specified 2	UKB Axiom/BiLEVE	1473	362366	5668	246.0
EoE-1	Omni2.5/Omni5	1033	11354	3787	11.0

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Table

EoE susceptibility by genetic variant

SNP filter method:

None

Band

Nearest Gene

Select dataset P-value to sort by:

EoE comb

EoE 1

EoE 2

EoE v non atopic

EoE v atopic

EoE atopic MTAG

Select band:

Select nearest protein coding gene:

SNPs (Ascending p-value order):

In the most expansive EoE susceptibility analysis to date, 17k variants genome-wide showed a putative association with EoE genetic susceptibility. Variants can be searched by rsid, band, or nearest gene.

Data are available for the 17k variants that met any of the following criteria: p<1e-4 EoE comb, EoE 1, EoE 2, EoE v non atopic, or EoE v atopic
p<1e-6 EoE atopic MTAG

Dataset Information:

Dataset	Platform	Cases	Controls	Neff	Cn/Cs Ratio
EoE-comb	-	1757	14467	6137	8.2
EoE-1	Omni2.5/Omni5	1033	11354	3781	11.0
EoE-2	GSA/Omni2.5/Omni5	724	3113	2350	4.3
EoE vs. UKB atopic (EoE-atopy)	GSA/Omni2.5/Omni5/UKB Axiom	1757	8959	5876	5.1
EoE vs. UKB non- atopic (EoE-no-atopy)	GSA/Omni2.5/Omni5/UKB Axiom	1757	8763	5854	5.0

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GWAS Viewer

EoE atopic MTAG

EoE susceptibility by genetic variant