EGID Express GWAS

EoE₁-atopy-MTAG

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SNP filter method:

None

Band

Nearest Gene

Manual P-value Threshold

Manual P-value Threshold and Band

Manual P-value Threshold and Nearest Gene

Select band:

Select nearest protein coding gene:

Enter maximum EoE₁ P-value:
Range = 1 to 5e-10
Format as decimals or scientific notation (i.e. 0.00005 or 5e-5)

Select band:

Enter maximum EoE₁ P-value:
Range = 1 to 5e-10
Format as decimals or scientific notation (i.e. 0.00005 or 5e-5)

Select nearest protein coding gene:

SNPs (Ascending EoE₁-atopy-MTAG P-value order):

Dataset Information:

Dataset	Platform	Cases	Controls	Neff	Cn/Cs Ratio
Asthma	UKB Axiom/BiLEVE	39409	362366	142174	9.2
Allergic rhinitis	UKB Axiom/BiLEVE	30197	330089	110664	10.9
Atopic dermatitis	UKB Axiom/BiLEVE	13090	330089	50363	25.2
Allergy not specified 1	UKB Axiom/BiLEVE	9345	362366	36440	38.8
Allergy not specified 2	UKB Axiom/BiLEVE	1473	362366	5668	246.0
EoE₁	Omni2.5/Omni5	1033	11354	3787	11.0

Graph
Table

EoE susceptibility by genetic variant

SNP filter method:

None

Band

Nearest Gene

Select dataset P-value to sort by:

EoE_T

EoE₁

EoE₂

EoE_T v. Nonatopic

EoE_T v. Atopic

EoE₁-atopy-MTAG

Select band:

Select nearest protein coding gene:

SNPs (Ascending P-value order):

In the most expansive EoE susceptibility analysis to date, 17k variants genome-wide showed a putative association with EoE genetic susceptibility. Variants can be searched by rsid, band, or nearest gene.

Data are available for the 17k variants that met any of the following criteria: p<1e-4 EoE_T, EoE₁, EoE₂, EoE_T v. Nonatopic, or EoE_T v. Atopic
p<1e-6 EoE₁-atopy-MTAG

Dataset Information:

Dataset	Platform	Cases	Controls	Neff	Cn/Cs Ratio
EoE_T	-	1757	14467	6137	8.2
EoE₁	Omni2.5/Omni5	1033	11354	3781	11.0
EoE₂	GSA/Omni2.5/Omni5	724	3113	2350	4.3
EoE_T v. Nonatopic	GSA/Omni2.5/Omni5/UKB Axiom	1757	8959	5876	5.1
EoE_T v. Atopic	GSA/Omni2.5/Omni5/UKB Axiom	1757	8763	5854	5.0

Graph
Table

GWAS Viewer

Enter SNP of interest below.
This tab contains all SNPs in EoE_T, EoE₁, EoE₂, EoE_T v. Nonatopic or EoE_T v. Atopic regardless of significance.
Auto-fill is not available for this field.

SNP:

Dataset Information:

Dataset	Platform	Cases	Controls	Neff	Cn/Cs Ratio
EoE_T	-	1757	14467	6137	8.2
EoE₁	Omni2.5/Omni5	1033	11354	3781	11.0
EoE₂	GSA/Omni2.5/Omni5	724	3113	2350	4.3
EoE_T v. Nonatopic	GSA/Omni2.5/Omni5/UKB Axiom	1757	8959	5876	5.1
EoE_T v. Atopic	GSA/Omni2.5/Omni5/UKB Axiom	1757	8763	5854	5.0

Graph
Table

EoE1-atopy-MTAG

EoE susceptibility by genetic variant

GWAS Viewer

EoE₁-atopy-MTAG